Cancer Pathway Charts

               STOP Cancer Chart

Below in the STOP Cancer chart are other pathways and mechanisms that help stop cancer.

This chart targets commonly dysregulated pathways and mechanisms in cancer such as:

Angiogenisis-Blood supply to tumor.

IGF-1– A natural hormone that can fuel cancer.

Foods that cause apoptosis– Foods that can kill cancer stem cells.

It makes sense to cover all the bases you can to make your body inhospitable to cancer!

To print click here!

Colorectal Cancer Map

 

https://www.genome.jp/kegg-bin/show_pathway?hsa05210

Common Dysregulated Pathways in Colorectal Cancer!

APC  (Adenomatous Polyposis Coli) is a gene mutation associated with the hereditary condition called FAP (Familial Adenomatous Polyposis) that causes polyps to grow that may become cancerous.

One study found curcumin combined with resveratrol had a synergistic effect in preventing cancer cell growth in FAP patients!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205744/

  • Curcumin AND Resveratrol together

Wnt-Beta Catenin  is often overexpressed in  colorectal cancer.  It controls cell proliferation, cell migration and cell fate and over expression can cause genetic mutations. Wnt signaling pathway overexpression is associated with loss of function of the tumor regulator APC. The Wnt pathway cross talks with the Notch and Sonic Hedgehog pathways as well. The substances below have been found to inhibit Wnt pathway activation.

  • Artemisinin-POTENT
  • Curcumin
  • Black Seed Oil
  • Carrots
  • Apigenin (Celery)
  • I3C-POTENT (Broccoli Sprouts)
  • Black Seed Oil
  • Garlic  fresh

P13k Regulates cell survival, proliferation and increased expression is associated with tumor progression.  When over expressed it reduces apoptosis (cell death) and allows proliferation. The substances below have been shown to inhibit expression of P13k.

  • Black Seed Oil
  • Resveratrol (Grapes)
  • EGCG (Green tea)
  • Quercetin
  • Fisetin (strawberries 37 per day dose)
  • Luteolin
  • Agigenin (Celery)
  • I3C and Sulforaphane (Broccoli Sprouts)
  • Ellagic Acid (Berries)
  • Curcumin
  • Carrots

Here is a great study with a nice chart-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736021/

PTEN Is a tumor suppressor gene, so you want to activate it so it can suppress tumors. It’s also involved in genomic integrity or quality control of cells.  Loss of PTEN expression decreases another tumor suppressor gene called P53.   Below is a fantastically positive announcement about broccoli sprouts and PTEN!

COX-2   Is associated with inflammation which induces cancer.  It promotes angiogenesis (blood supply to tumor) and tissue invasion of tumors and resistance to apoptosis (cell death). The substances below inhibit COX-2.

  • Black seed oil-POTENT
  • Apigenin (Celery)
  • Beta-carotene (Carrots)
  • Curcumin
  • EGCG (Green Tea)
  • Sulforaphane and I3C (broccoli sprouts)
  • Vitamin C
  • Resveratrol (Grapes)
  • Garlic
  • Carrots
  • And more..

PPAR  (Peroxisome Proliferator-activated receptors) This suppresses tumors, so you want to activate it!  When PPAR is activated, COX2 decreases allowing apoptosis (cell death).  The substances below  have been found to activate PPAR

  • Curcumin
  • EGCG  (Green Tea)
  • Resveratrol (Grapes)
  • Beta-carotene (Carrots)
  • Apigenin (Celery)
  • Lycopene (Cooked tomato)
  • I3C- Broccoli Sprouts
  • Carrots

P53- This is a tumor suppressor gene so you want to activate it! When it’s activated, it stops mutated or damaged cells from dividing by causing apoptosis (cell death) preventing the formation of tumors.  The substances below have been shown to activate P53.

  • Berberine-POTENT (supplement)
  • Apigenin-POTENT (celery)
  • Curcumin
  • EGCG (Green Tea)
  • Resveratrol (Grapes)
  • Betacarotene (Carrots)
  • I3C and Sulphoraphane (Broccoli Sprouts)
  • Ginger
  • Garlic
  • Black Seed Oil
  • Carrots

mTOR–  is often overexpressed in colorectal cancer.  Mtor overexpression drives cancer cell growth and angiogenesis. The substances below inhibit mTOR.

  • Eliminate animal products
  • Curcumin
  • EGCG (Green Tea
  • Resveratrol (Grapes)
  • Luteolin (Radicchio, Carrots)
  • Apigenin (Celery)
  • Quercetin
  • Indol-3 (Broccoli Sprouts)
  • Berberine (Supplement)
  • Black Seed Oil
  • Garlic

TGF-Beta-is a tumor suppressor gene.  When activated it decreases proliferation of cancer cells and increases cancer cell death (apoptosis).  The substances below activate TGF-Beta.

  • Apigenin-POTENT (Celery)
  • Luetolin (carrots or radicchio)
  • Quercetin
  • Vitamin C
  • I3C (Broccoli Sprouts)
  • Berberine (Supplement)
  • Black Seed Oil
  • Garlic

EGFR Is commonly overexpressed in colorectal cancer.  It regulates cell division and death.

  • EGCG (Green Tea)
  • Curcumin

Per table-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327764/

MAPK– Overexpressed in many cancers. It regulates gene expression, cell growth and survival.  Increased MAPK signaling leads to uncontrolled cell proliferation and resistance to apoptosis (cell death).  The substances below inhibit MAPK expression.

  • EGCG (Green Tea)
  • Berberine
  • I3C (Broccoli Sprouts)

VEGF (Vascular Endothelial Growth factor) is often overexpressed in cancer. VEGF stimulates vascular (blood vessels to tumor) cell growth, survival, and proliferation.

  • Burdock root-POTENT (Essiac Tea)
  • Artemisinin
  • EGCG (Green Tea)
  • Apigenin (Celery)
  • I3C and Sulforaphane (Broccoli Sprouts)

EGFR (Epidermal growth factor receptor) is a protein on the surface of cells. It normally helps the cells grow and divide.  The substances below inhibit EGFR.

  • Curcumin
  • EGCG (Green Tea)
  • Resveratrol (Grapes)
  • Luteolin (Radicchio)
  • Apigenin (Celery)
  • I3C – (Broccoli Sprouts)
  • Berberine (Supplement)
  • Burdock (Essiac)
  • Black Seed Oil
  • Garlic

 

Endless studies support that a bacteria called Fusobacterium could be the CAUSE of colorectal cancer.

In colorectal cancer there’s an overgrowth of Fusobacterium and a deficiency of a protective  bacteria called Lachnospiraceae.

The Standard American Diet fuels Fusobacterium.  A whole food plant based diet has been proven to change the microbiome in as little as 24 hours increasing levels of Lachnospiraceae.

Here is a list I’ve made of substances that increase Lachnospiraceae while inhibiting Fusobacterium.

 

                                                           Thinking of trying Fenbendazole? 

I was really excited about it until three people I know with colorectal cancer who were previously stable had aggressive metastasis all in one week.  Then I started tracking cases and became very concerned. 

Here are the results of my research so far. There are no human studies, so animal will have to do for now.

  • aFT3 is induced by FB.  aFT3 activation promotes colorectal cancer metastasis.  
  • IL-8  is upregulated further by FB and promotes cancer cell migration and aggressiveness.  Problem; IL-8 and its receptor CXCR2 are two of the most significantly upregulated chemokines in colorectal cancer.  
  • At low doses FB decreases Connexin 32 significantly; Connexins fill gap junctions in the intestines.  They are also tumor suppressors.  Colorectal cancer is associated with loss of connexin expression.  They are critical for extracellular communication. 
  • P450  Fenbendazole upregulates P450.  Increased P450 indicates poor prognosis in CRC.. Higher levels of P450 equal less detox and can turn procarcinogens into carcinogens.  
  • In this study FB has been found to promote 33 genes for cancer “In conclusion, we here found 33 genes showing altered expression specific to the early stages of tumor promotion by fenbendazole.”  This study showed suppression of PTEN (A major tumor suppresser) and upregulation of many tumor promotors.  

Loss of villus epithelium and stroma within the small intestine of mammals. Passing tissue? Gastric pain? 

Fenbendazole kills Lachnospiraceae (protective of CRC) and most all bacteria hence the diarrhea, Cdiff, gastric pain.  If cancer Is driven by bacteria this could provide temp shrinkage then resistance and then a roaring comeback.  

Liver Tumor Promoting Effects of Fenbendazole in Rats.  

“Since those agents that induce CYP 2B1/2 isozymes and reduce Cx32 in centrilobular hepatocytes have been suggested to be liver tumor promoters, the present results indicate that fenbendazole may be a liver tumor promoter.” 

Increased tumor growth in the fenbendazole only treatment group.  “Fenbendazole may have tumor-promoting activity in rats at therapeutic dosages (that is, through inhibition of connexin 32 and induction of cytochrome P450 enzymes 1A1 and 1A2).”  

  • Can cause Immune suppression of B and T cells and long-term severe effects in an autoimmune disease in mice that mimics Multiple Sclerosis.  

We have a gene that makes us more sensitive to Fenbendazole than rats.  Rats have to by “humanized” with this gene for comparison in lab studies. There are also slow metabolizers and fast. 

  • There are multiple parabens in the goat dewormer, not sure about other formulations. 
  • MSDS Toxicity data 
  • Liver is the main target but also stomach, kidneys, blood, immune system, and central nervous system were affected. 
  •  High doses; renal, encephalomalacia, satellitosis, neuronophagia, perivascular inflammation or gliosis, hyperplasia and congestion of the mesenteric lymph nodes   
  • Cyst formation in lymph nodesliver mass and/or nodule formation, and testicular masses were reported.   
    • https://www.cvear.com/wp-content/uploads/2012/06/078335976.pdf 

Bone Marrow Hypoplasia Associated With Fenbendazole Administration in a Dog; sudden-onset of fever and malaise with low WBC count and bone marrow hypoplasia. Symptoms resolved in 15 days when Fenbendazole was stopped.  

Potent interactions with acetaminophen in mice which led to 63% mortality 

“No effect on tumors in mice our studies provided no evidence that fenbendazole warrants further testing as a potential agent for use in cancer therapy”. 

Conclusion; Although the chemical structure of fenbendazole is similar to menbendazole (approved for humans), it works differently.  I think we’ll know a lot more about it’s effects on humans in the future and for now I think it’s wise to avoid, especially if you’re stable.   I have noticed some positive results when combined with immunotherapy as Joe Tippins did.  So that is something to be watching!

To print Natural Compounds that Work Similar to Fenbendazole, click here!