Cancer Pathway Charts!

If you’ve read cancer survivor Jane McClelland’s book How to Starve Cancer this post will make sense and I highly recommend the book!

If you haven’t read the book, Jane has made a map of natural substances and off label drugs that starve cancer cells of fuel by blocking sugar (glucose), fatty acids (fat), and an amino acid (glutamine).

After reading her book I wondered if there were plant substances that worked the same way?

I spend weeks researching and documenting plant compounds and pathways and when finished, I added additional amino acids in the blue box that were also associated with cancer cell growth and remedied by diet.

Glutamine side of the triangle; those that know my story will know that the best way I have found to block glutamine is diet. No drugs could control my symptoms of excess glutamate consumption that food additives and food processing caused.

Certain food additives are sky high in free glutamate (the kind caused by heating or degrading a protein) which causes nerves to rapid fire AND also fuels cancer cells. These additives can even be found in organic products under certain names like “natural flavors”, guar gum, xanthan gum, and more. Go to my Hidden Names for MSG list, for high glutamate additives to avoid.

Wheat and diary are two foods that are high in bound glutamate, the natural unprocessed normally not harmful form. People tend to have large quantity of dairy and wheat in their diets, so removing those two can really put a dent in the amount of glutamate consumed!

On to the glucose side of the triangle; I noticed something interesting; there are compounds in carrots that block sugar. COOL!

That might explain the drop in Casey’s blood sugar. It was 110 FASTING prior to diet change before his diagnosis. After being on Square One for a while and eating over 5 lbs. carrots, one bunch celery and smoothie a day, his NON-fasting blood sugar was 70! Notice apigenin (celery) is on the sugar blocking side as well, and many other substances he consumes.

In a collaborative effort Chris Wark (Chrisbeatcancer.com) and I got this chart finished, polished up, and ready to be displayed to the masses!

Click here to print!

 

STOP Cancer Chart

Below in the STOP Cancer chart are other pathways and mechanisms that help stop cancer.

This chart targets commonly dysregulated pathways and mechanisms in cancer such as:

Angiogenisis-Blood supply to tumor.

IGF-1– A natural hormone that can fuel cancer.

Foods that cause apoptosis– Foods that can kill cancer stem cells.

It makes sense to cover all the bases you can to make your body inhospitable to cancer!

To print click here!

Colorectal Cancer Map

 

https://www.genome.jp/kegg-bin/show_pathway?hsa05210

Common Dysregulated Pathways in Colorectal Cancer!

APC  (Adenomatous Polyposis Coli) is a gene mutation associated with the hereditary condition called FAG (Familial Adenomatous Polyposis) that causes polyps to grow that may become cancerous.

One study found curcumin combined with resveratrol had a synergistic effect in preventing cancer cell growht in FAP patients!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205744/

  • Curcumin AND Resveratrol together

Wnt-Beta Catenin  is often overexpressed in  colorectal cancer.  It controls cell proliferation, cell migration and cell fate and over expression can cause genetic mutations. Wnt signaling pathway overexpression is associated with loss of function of the tumor regulator APC. The Wnt pathway cross talks with the Notch and Sonic Hedgehog pathways as well. The substances below have been found to inhibit Wnt pathway activation.

  • Artemisinin-POTENT
  • Curcumin
  • Black Seed Oil
  • Carrots
  • Apigenin (Celery)
  • I3C-POTENT (Broccoli Sprouts)
  • Black Seed Oil
  • Garlic  fresh

P13k Regulates cell survival, proliferation and increased expression is associated with tumor progression.  When over expressed it reduces apoptosis (cell death) and allows proliferation. The substances below have been shown to inhibit expression of P13k.

  • Black Seed Oil
  • Resveratrol (Grapes)
  • EGCG (Green tea)
  • Quercetin
  • Fisetin (strawberries 37 per day dose)
  • Luteolin
  • Agigenin (Celery)
  • I3C and Sulforaphane (Broccoli Sprouts)
  • Ellagic Acid (Berries)
  • Curcumin
  • Carrots

Here is a great study with a nice chart-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736021/

PTEN Is a tumor suppressor gene, so you want to activate it so it can suppress tumors. It’s also involved in genomic integrity or quality control of cells.  Loss of PTEN expression decreases another tumor suppressor gene called P53.   Below is a fantastically positive announcement about broccoli sprouts and PTEN!

COX-2   Is associated with inflammation which induces cancer.  It promotes angiogenesis (blood supply to tumor) and tissue invasion of tumors and resistance to apoptosis (cell death). The substances below inhibit COX-2.

  • Black seed oil-POTENT
  • Apigenin (Celery)
  • Beta-carotene (Carrots)
  • Curcumin
  • EGCG (Green Tea)
  • Sulforaphane and I3C (broccoli sprouts)
  • Vitamin C
  • Resveratrol (Grapes)
  • Garlic
  • Carrots
  • And more..

PPAR  (Peroxisome Proliferator-activated receptors) This suppresses tumors, so you want to activate it!  When PPAR is activated, COX2 decreases allowing apoptosis (cell death).  The substances below  have been found to activate PPAR

  • Curcumin
  • EGCG  (Green Tea)
  • Resveratrol (Grapes)
  • Beta-carotene (Carrots)
  • Apigenin (Celery)
  • Lycopene (Cooked tomato)
  • I3C- Broccoli Sprouts
  • Carrots

P53- This is a tumor suppressor gene so you want to activate it! When it’s activated, it stops mutated or damaged cells from dividing by causing apoptosis (cell death) preventing the formation of tumors.  The substances below have been shown to activate P53.

  • Berberine-POTENT (supplement)
  • Apigenin-POTENT (celery)
  • Curcumin
  • EGCG (Green Tea)
  • Resveratrol (Grapes)
  • Betacarotene (Carrots)
  • I3C and Sulphoraphane (Broccoli Sprouts)
  • Ginger
  • Garlic
  • Black Seed Oil
  • Carrots

mTOR–  is often overexpressed in colorectal cancer.  Mtor overexpression drives cancer cell growth and angiogenesis. The substances below inhibit mTOR.

  • Eliminate animal products
  • Curcumin
  • EGCG (Green Tea
  • Resveratrol (Grapes)
  • Luteolin (Radicchio, Carrots)
  • Apigenin (Celery)
  • Quercetin
  • Indol-3 (Broccoli Sprouts)
  • Berberine (Supplement)
  • Black Seed Oil
  • Garlic

TGF-Beta-is a tumor suppressor gene.  When activated it decreases proliferation of cancer cells and increases cancer cell death (apoptosis).  The substances below activate TGF-Beta.

  • Apigenin-POTENT (Celery)
  • Luetolin (carrots or radicchio)
  • Quercetin
  • Vitamin C
  • I3C (Broccoli Sprouts)
  • Berberine (Supplement)
  • Black Seed Oil
  • Garlic

EGFR Is commonly overexpressed in colorectal cancer.  It regulates cell division and death.

  • EGCG (Green Tea)
  • Curcumin

Per table-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327764/

MAPK– Overexpressed in many cancers. It regulates gene expression, cell growth and survival.  Increased MAPK signaling leads to uncontrolled cell proliferation and resistance to apoptosis (cell death).  The substances below inhibit MAPK expression.

  • EGCG (Green Tea)
  • Berberine
  • I3C (Broccoli Sprouts)

VEGF (Vascular Endothelial Growth factor) is often overexpressed in cancer. VEGF stimulates vascular (blood vessels to tumor) cell growth, survival, and proliferation.

  • Burdock root-POTENT (Essiac Tea)
  • Artemisinin
  • EGCG (Green Tea)
  • Apigenin (Celery)
  • I3C and Sulforaphane (Broccoli Sprouts)

EGFR (Epidermal growth factor receptor) is a protein on the surface of cells. It normally helps the cells grow and divide.  The substances below inhibit EGFR.

  • Curcumin
  • EGCG (Green Tea)
  • Resveratrol (Grapes)
  • Luteolin (Radicchio)
  • Apigenin (Celery)
  • I3C – (Broccoli Sprouts)
  • Berberine (Supplement)
  • Burdock (Essiac)
  • Black Seed Oil
  • Garli